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A vertical mouse holds your hand in a handshake position, which some people find easier on the wrist than a flat mouse. Most vertical mice are built for comfort rather than competitive FPS.
This guide covers six vertical mice sold on Amazon. It is built from product listings, not our own testing. Ergonomic claims are the makers’, and a mouse cannot treat a medical condition: see a professional for wrist pain.
New to gaming mice? Read our gaming mouse buying guide.
Last updated: October 30, 2026.
Quick Picks
| Product | Type | Best for |
|---|---|---|
| Razer Pro Click V2 Vertical | Vertical wireless mouse | A six-button vertical design |
| Logitech MX Vertical | Ergonomic vertical mouse | A 57-degree handshake position |
| Wireless Vertical Gaming Mouse (24,000 DPI, 12 buttons) | Vertical gaming mouse | A vertical gaming mouse with 12 buttons |
| TRELC Wired Vertical Gaming Mouse | Wired vertical gaming mouse | 11 buttons and a 5-direction rocker |
| DELUX M618PLUS Vertical Mouse | Wired vertical mouse for large hands | A vertical shape sized for larger hands |
| Uineer Vertical Ergonomic Wireless Mouse | Wireless vertical mouse | Three-device wireless vertical mouse |
6 Best Vertical Ergonomic Mice for Gaming and Work
1. Razer Pro Click V2 Vertical
A vertical wireless mouse with six buttons and a base support, designed for a natural handshake grip, per the listing.
Good for: People who want a vertical mouse with Razer software. Strengths: Comfortable handshake angle and base support. Weaknesses: Not aimed at fast FPS play. Skip it if you want an esports mouse.
2. Logitech MX Vertical
A wireless vertical mouse with a 57-degree angle; Logitech says it reduces muscular activity by 10 percent compared with a standard mouse.
Good for: Anyone with wrist strain who wants a productivity-first vertical mouse. Strengths: Well-known ergonomic design. Weaknesses: Not built for competitive gaming. Skip it if you want a gaming-focused sensor and weight.
3. Wireless Vertical Gaming Mouse (24,000 DPI, 12 buttons)
A tri-mode vertical gaming mouse with 12 programmable buttons and up to 24,000 DPI, marketed for wrist pain relief, per the listing.
Good for: Users who want a vertical mouse for gaming and work. Strengths: Tri-mode connection and many buttons. Weaknesses: A lesser-known brand; ergonomic claims are the maker’s. Skip it if you want a name-brand sensor.
4. TRELC Wired Vertical Gaming Mouse
A wired vertical mouse with 11 programmable buttons, a 5-direction rocker, 10,000 DPI and on-board memory, per the listing.
Good for: Gamers who want a wired vertical mouse. Strengths: Extra buttons and on-board memory. Weaknesses: Lesser-known brand; wired. Skip it if you want wireless.
5. DELUX M618PLUS Vertical Mouse
A wired ergonomic vertical mouse designed for larger hands with RGB lighting, per the listing.
Good for: Users with big hands who want a vertical shape. Strengths: Designed for larger hands. Weaknesses: Wired and not a gaming sensor. Skip it if you have small hands.
6. Uineer Vertical Ergonomic Wireless Mouse
A wireless vertical mouse that pairs with three devices over Bluetooth or 2.4 GHz, with ambient lighting.
Good for: Office-first users who also game casually. Strengths: Three-device pairing and a natural handshake grip. Weaknesses: Not a gaming-focused sensor. Skip it if you play competitive games.
How to Choose
Try it for work first
A vertical mouse takes time to adapt to. Use it for office work before gaming.
Check size
Some vertical mice are sized for larger hands.
Wired or wireless
Wireless is tidier. Wired avoids charging.
Frequently Asked Questions
Are vertical mice good for gaming?
Some are, especially for slow-paced games. Fast FPS play often prefers lightweight conventional mice.
Do vertical mice help carpal tunnel?
Makers claim comfort benefits. Ask a clinician about medical issues.
Is there a wireless vertical gaming mouse?
Yes, see the listings above.
Bottom Line
For comfort-first use, the Logitech MX Vertical is the established pick, and the Razer Pro Click V2 Vertical is the Razer option. For gaming-style features, look at the TRELC or the 12-button wireless model.
More Gaming Mouse Guides
- Gaming Mouse Buying Guide
- Best Mouse Grip for Gaming
- Best Wireless Gaming Mice
- Best Budget Gaming Mice
